홍창완
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- chong@pusan.ac.kr
2007 PhD; Cellular Immunology; Korea University, Seoul, Korea
2007-2008 Research professor, Korea University, Seoul, Korea
2008 Visiting Fellow, Stanford University, Palo Alto, CA
2008-2013 Visiting Fellow, EIB/NCI/NIH, Bethesda, MD
2013-present Assistant professor, Department of Anatomy, School of medicine, Pusan National University, Yangsan, Korea
2008 Visiting Fellow, Stanford University, Palo Alto, CA
2008-2013 Visiting Fellow, EIB/NCI/NIH, Bethesda, MD
2013-present Assistant professor, Department of Anatomy, School of medicine, Pusan National University, Yangsan, Korea
1. American Association of Immunologists 90th Annual Meeting, “NKT cell-dependent adjuvant effect of alpha-galactosyl ceramide in tumor rejection”, Denver, CO, May 2003
2. International Cytokine Society Conference, “Regulation of NKT activation by the cytokine-mediated antigen presenting cells”, Seoul, Republic of Korea, Oct. 2005
3. Keystone Symposia, “CD4+ T cells in the absence of the CD8+ cytotoxic T cells are critical and sufficient for NKT cell-dependent tumor rejection”, Vancouver, Canada, Feb. 2007
4. IIG retreat, “Post-transcriptional Regulation of IL-7 Receptor (CD127) Expression by Alternative Splicing”, Gettysburg, MD, Sep. 2009
5. Joint meeting of the international cytokine society and the international society for interferon and cytokine research, “Active regulation of common gamma chain is critical for T cell development and homeostasis”, Chicago, IL, Oct. 2010
6. Baltimore/Washington Metropolitan Area Life Scientists Poster Symphosium, “A novel mechanism of regulating ?c cytokine signaling by a soluble form of common gamma chain”, Baltimore, MD, May 2011
7. ThymUS2012, “Active regulation of common gamma chain is critical for T cell development and homeostasis”, Miami, FL, Nov. 2012
8. NHLBI Mitochondrial Biology Symposium, “Ikaros induces mitochondrial-dependent apoptosis, inhibiting BAG3 expression”, Bethesda, MD, May. 2013
2. International Cytokine Society Conference, “Regulation of NKT activation by the cytokine-mediated antigen presenting cells”, Seoul, Republic of Korea, Oct. 2005
3. Keystone Symposia, “CD4+ T cells in the absence of the CD8+ cytotoxic T cells are critical and sufficient for NKT cell-dependent tumor rejection”, Vancouver, Canada, Feb. 2007
4. IIG retreat, “Post-transcriptional Regulation of IL-7 Receptor (CD127) Expression by Alternative Splicing”, Gettysburg, MD, Sep. 2009
5. Joint meeting of the international cytokine society and the international society for interferon and cytokine research, “Active regulation of common gamma chain is critical for T cell development and homeostasis”, Chicago, IL, Oct. 2010
6. Baltimore/Washington Metropolitan Area Life Scientists Poster Symphosium, “A novel mechanism of regulating ?c cytokine signaling by a soluble form of common gamma chain”, Baltimore, MD, May 2011
7. ThymUS2012, “Active regulation of common gamma chain is critical for T cell development and homeostasis”, Miami, FL, Nov. 2012
8. NHLBI Mitochondrial Biology Symposium, “Ikaros induces mitochondrial-dependent apoptosis, inhibiting BAG3 expression”, Bethesda, MD, May. 2013
1. Hong C, Luckey MA, Ligons DL, Waickman AT, Park JY, Kim, GY, Keller HR, Etzensperger R, Tai X, Lazarevic V, Feigenbaum L, Catalfamo M, Walsh STR, and Park JH.: Activated T cells secrete an alternatively spliced form of the common ?-chain cytokine receptor that impairs ?c cytokine signaling and is responsible for the severity of Th17-mediated autoimmune disease. Immunity 2014. (in press)
2. Hong C*, Nam AS*, Keller HR, Ligons DL, Park JY, Yoon HW, Park JJ, Luckey MA, Park JH.: Interleukin-6 expands homeostatic space for peripheral T cells. Cytokine 64:532-40, 2013. (*Equal contribution)
3. Hasley RB, Hong C, Li W, Friesen T, Nakamura Y, Kim GY, Park JH, Hixon JA, Durum S, Hu Z, Sneller MC, Oguariri R, Imamichi T, Lane HC, Catalfamo M.: HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127. AIDS 27:1867-77, 2013.
4. Tinsley KW*, Hong C*, Luckey MA, Kim GY, Keller HR, Sacks AJ, Feigenbaum L and Park JH.: Ikaros is required to survive positive selection and to maintain clonal diversity during T cell development in the thymus. Blood 122:2358-68, 2013 (*Equal contribution)
-Featured in Inside blood. 122:2358-2359, 2013
5. Linowes BA, Nam AS, Ligons DL, Hong C, Keller HR, Tai X, Luckey MA, and Park JH.: Pim1 permits generation and homeostasis of CD4+ T cells in the absence of ?c cytokine receptor signaling. Eur J Immunol. 43:2283-94, 2013
6. Subhan F, Yoon TD, Choi HJ, Muhammad I, Lee J, Hong C, Oh SO, Baek SY, Kim BS, Yoon S.: Epidermal growth factor-like domain 8 inhibits the survival and proliferation of mouse thymocytes. Int J Mol Med. 32:952-8, 2013.
7. Kim GY, Ligons DL, Hong C, Luckey MA, Keller HR, Tai X, Lucas PJ, Gress RE, Park JH.: An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis. J Immunol. 188:5859-66, 2012.
8. Hong C, Luckey MA, Park JH.: Intrathymic IL-7: the where, when, and why of IL-7 signaling during T cell development. Semin Immunol. 24:151-8, 2012.
9. Tikhonova AN, Van Laethem F, Hanada K, Lu J, Pobezinsky LA, Hong C, Guinter TI, Jeurling SK, Bernhardt G, Park JH, Yang JC, Sun PD, Singer A.: αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities. Immunity. 36:79-91, 2012.
10. Kim GY, Hong C, Park JH.: Seeing is believing: illuminating the source of in vivo interleukin-7. Immune Netw. 11:1-10, 2011.
11. Shin Y, Hong C, Lee H, Shin JH, Hong S, Park SH.: NKT cell-dependent regulation of secondary antigen-specific, conventional CD4+ T cell immune responses. J Immunol. 184:5589-5594, 2010.
2. Hong C*, Nam AS*, Keller HR, Ligons DL, Park JY, Yoon HW, Park JJ, Luckey MA, Park JH.: Interleukin-6 expands homeostatic space for peripheral T cells. Cytokine 64:532-40, 2013. (*Equal contribution)
3. Hasley RB, Hong C, Li W, Friesen T, Nakamura Y, Kim GY, Park JH, Hixon JA, Durum S, Hu Z, Sneller MC, Oguariri R, Imamichi T, Lane HC, Catalfamo M.: HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127. AIDS 27:1867-77, 2013.
4. Tinsley KW*, Hong C*, Luckey MA, Kim GY, Keller HR, Sacks AJ, Feigenbaum L and Park JH.: Ikaros is required to survive positive selection and to maintain clonal diversity during T cell development in the thymus. Blood 122:2358-68, 2013 (*Equal contribution)
-Featured in Inside blood. 122:2358-2359, 2013
5. Linowes BA, Nam AS, Ligons DL, Hong C, Keller HR, Tai X, Luckey MA, and Park JH.: Pim1 permits generation and homeostasis of CD4+ T cells in the absence of ?c cytokine receptor signaling. Eur J Immunol. 43:2283-94, 2013
6. Subhan F, Yoon TD, Choi HJ, Muhammad I, Lee J, Hong C, Oh SO, Baek SY, Kim BS, Yoon S.: Epidermal growth factor-like domain 8 inhibits the survival and proliferation of mouse thymocytes. Int J Mol Med. 32:952-8, 2013.
7. Kim GY, Ligons DL, Hong C, Luckey MA, Keller HR, Tai X, Lucas PJ, Gress RE, Park JH.: An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis. J Immunol. 188:5859-66, 2012.
8. Hong C, Luckey MA, Park JH.: Intrathymic IL-7: the where, when, and why of IL-7 signaling during T cell development. Semin Immunol. 24:151-8, 2012.
9. Tikhonova AN, Van Laethem F, Hanada K, Lu J, Pobezinsky LA, Hong C, Guinter TI, Jeurling SK, Bernhardt G, Park JH, Yang JC, Sun PD, Singer A.: αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities. Immunity. 36:79-91, 2012.
10. Kim GY, Hong C, Park JH.: Seeing is believing: illuminating the source of in vivo interleukin-7. Immune Netw. 11:1-10, 2011.
11. Shin Y, Hong C, Lee H, Shin JH, Hong S, Park SH.: NKT cell-dependent regulation of secondary antigen-specific, conventional CD4+ T cell immune responses. J Immunol. 184:5589-5594, 2010.